HPV Treatment Regimens for Genital Warts

Removal is the Primary Focus

The primary focus of treating vaginal warts is their removal and in the majority of cases treatment can achieve this goal. It is possible that vaginal warts will resolve themselves with time. They may remain unchanged or conversely, they may multiply and spread. HPV infection is not eliminated with treatment, although it can possibly be reduced in its strength. There are many variables.

Developing Treatments

There are a few factors to consider when developing a treatment for a person with HPV vaginal warts. The preference of the patient, availability of resources and the experience of the medical professional are all considerations. There is no available evidence to suggest that one method of treatment is superior to any of the others and there is no single treatment that is right for all patients. Locally developed and monitored treatment algorithms are connected with better clinical outcomes and are encouraged. Overall, HPV patients require a regimen or course of therapy rather than a single treatment and the treatment should be changed if the personal has not improved within a three month period.

Rarely do complications occur but there are commonly cases of change in pigmentation with some treatments. Scarring is not common, but can occur and in occasional cases, there can be pain and discomfort. The treatments can be either patient-applied or provider-applied with the bulk of cream and topical applications being done by the patient.


Podofilox solution can be applied to the infected area by the person infected in a specific cycle indicated by the health care professional. Imiquimod cream can also be applied by the individual however a health care provider will administer cryotherapy with liquid nitrogen, podophyllin resin or trichloracetic acid (TCA or bichloroacetic acid (BCA). Surgical removal can only be done by a medical professional.

Surgery and Topicals

Cervical warts require that a high-grade SIL must be excluded before treatment is initiated. A specialist should be consulted for management of this type of HPV wart situation. Vaginal warts can be treated with a regimen of cryotherapy or TCA or BCA. Urethral meatus warts are treated with cryotherapy or podophyllin compound. Anal warts are also treated with cryotherapy or TCA or BCA or they can be surgically removed. A specialist should be consulted in cases where warts are on the rectal or anal mucosa.


Another vital and necessary part of the treatment program is the education and counseling of people with HPV genital warts. It is important to convey that genital HPV infection is quite common amongst sexually active adults and that it is usually sexually transmitted. Genital warts are caused by specific types of HPV infection which are different from the types that cause cervical or other types of cancers. It is common for genital warts to recur after treatment.


A follow-up evaluation is helpful for people with HPV genital warts. While the warts may disappear without treatment or be dealt with during treatment, the HPV virus remains in the body and warts may occur again at another time.